Extracellular Vesicle Mimetics: Preparation from Top‐Down Approaches and Biological Functions (Adv. Healthcare Mater. 19/2022)

Extracellular Vesicle Mimetics vesicles mimetics (EVMs) prepared from top-down approaches exhibit superiority both in production and biological properties as potential alternatives of extracellular (EVs). By extruding through membrane filters with decreased pore sizes, EVMs can be produced a large scale. In article 2200142, Chenhui Gu, Liqing Shangguan, Xianfeng Lin co-workers summarize the preparation characteristics terms structure, composition, targeting ability, cellular uptake mechanism, immunogenicity, well their strengths limitations. The clinical applications fields tumor therapy, immunomodulation, tissue repair disease diagnosis are also discussed.